1177767-57-5

1177767-57-5 structure

Name: Desmethyl-YM 298198
Chemical Name: Desmethyl-YM 298198
CAS Number: 1177767-57-5
Molecular Formula: C₁₇H₂₁ClN₄OS
Molecular Weight: 364.89
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2021-05-02 18:53:04
Modify Date: 2024-04-06 22:06:56
Desmethyl-YM-298198 hydrochloride is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC50: 16 nM). Desmethyl-YM-298198 hydrochloride has analgesic effect in Streptozotocin (HY-13753)-induced hyperalgesic mice[1].

Name	Desmethyl-YM 298198
Synonyms	MFCD08458897 6-Amino-N-cyclohexyl-3-methyl[1,3]thiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride (1:1) Thiazolo[3,2-a]benzimidazole-2-carboxamide, 6-amino-N-cyclohexyl-3-methyl-, hydrochloride (1:1)

Description	Desmethyl-YM-298198 hydrochloride is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC50: 16 nM). Desmethyl-YM-298198 hydrochloride has analgesic effect in Streptozotocin (HY-13753)-induced hyperalgesic mice[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	16 nM (mGluR1)[1]
References	[1]. Kohara A, et al. Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1. J Pharmacol Exp Ther. 2005 Oct;315(1):163-9.