Desmethyl-YM 298198

Modify Date: 2024-04-06 22:06:56

Desmethyl-YM 298198 Structure
Desmethyl-YM 298198 structure
Common Name Desmethyl-YM 298198
CAS Number 1177767-57-5 Molecular Weight 364.89
Density N/A Boiling Point N/A
Molecular Formula C17H21ClN4OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Desmethyl-YM 298198


Desmethyl-YM-298198 hydrochloride is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC50: 16 nM). Desmethyl-YM-298198 hydrochloride has analgesic effect in Streptozotocin (HY-13753)-induced hyperalgesic mice[1].

 Names

Name Desmethyl-YM 298198
Synonym More Synonyms

 Desmethyl-YM 298198 Biological Activity

Description Desmethyl-YM-298198 hydrochloride is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC50: 16 nM). Desmethyl-YM-298198 hydrochloride has analgesic effect in Streptozotocin (HY-13753)-induced hyperalgesic mice[1].
Related Catalog
Target

16 nM (mGluR1)[1]

References

[1]. Kohara A, et al. Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1. J Pharmacol Exp Ther. 2005 Oct;315(1):163-9.  

 Chemical & Physical Properties

Molecular Formula C17H21ClN4OS
Molecular Weight 364.89
Exact Mass 364.112457

 Synonyms

MFCD08458897
6-Amino-N-cyclohexyl-3-methyl[1,3]thiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride (1:1)
Thiazolo[3,2-a]benzimidazole-2-carboxamide, 6-amino-N-cyclohexyl-3-methyl-, hydrochloride (1:1)
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