1189656-59-4

1189656-59-4 structure

Name: Manidipine-d4
Chemical Name: Manidipine-d4
CAS Number: 1189656-59-4
Molecular Formula: C₃₅H₃₄D₄N₄O₆
Molecular Weight: 614.724
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2021-05-21 12:51:05
Modify Date: 2024-03-16 13:31:03
Manidipine-d4 is the deuterium labeled Manidipine. Manidipine is a calcium channel blocker that is used clinically as an antihypertensive[1][2].

Name	Manidipine-d4
Synonyms	2-[4-(Diphenylmethyl)-1-piperazinyl](2H4)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl-1,1,2,2-d4 methyl ester Manidipine-d4

Description	Manidipine-d4 is the deuterium labeled Manidipine. Manidipine is a calcium channel blocker that is used clinically as an antihypertensive[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Cheer, S.M. and K. McClellan, Manidipine: a review of its use in hypertension. Drugs, 2001. 61(12): p. 1777-99. [3]. McKeage, K. and L.J. Scott, Manidipine: a review of its use in the management of hypertension. Drugs, 2004. 64(17): p. 1923-40. [4]. Roca-Cusachs, A. and F. Triposkiadis, Antihypertensive effect of manidipine. Drugs, 2005. 65 Suppl 2: p. 11-9.