Manidipine-d4

Modify Date: 2024-03-16 13:31:03

Manidipine-d4 Structure
Manidipine-d4 structure
Common Name Manidipine-d4
CAS Number 1189656-59-4 Molecular Weight 614.724
Density 1.2±0.1 g/cm3 Boiling Point 722.0±60.0 °C at 760 mmHg
Molecular Formula C35H34D4N4O6 Melting Point N/A
MSDS N/A Flash Point 390.4±32.9 °C

 Use of Manidipine-d4


Manidipine-d4 is the deuterium labeled Manidipine. Manidipine is a calcium channel blocker that is used clinically as an antihypertensive[1][2].

 Names

Name Manidipine-d4
Synonym More Synonyms

 Manidipine-d4 Biological Activity

Description Manidipine-d4 is the deuterium labeled Manidipine. Manidipine is a calcium channel blocker that is used clinically as an antihypertensive[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Cheer, S.M. and K. McClellan, Manidipine: a review of its use in hypertension. Drugs, 2001. 61(12): p. 1777-99.

[3]. McKeage, K. and L.J. Scott, Manidipine: a review of its use in the management of hypertension. Drugs, 2004. 64(17): p. 1923-40.

[4]. Roca-Cusachs, A. and F. Triposkiadis, Antihypertensive effect of manidipine. Drugs, 2005. 65 Suppl 2: p. 11-9.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 722.0±60.0 °C at 760 mmHg
Molecular Formula C35H34D4N4O6
Molecular Weight 614.724
Flash Point 390.4±32.9 °C
Exact Mass 614.304260
LogP 5.46
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.601

 Synonyms

2-[4-(Diphenylmethyl)-1-piperazinyl](2H4)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl-1,1,2,2-d4 methyl ester
Manidipine-d4