1246820-82-5
1246820-82-5 structure
- Name: Tolfenamic Acid-d4
- Chemical Name: Tolfenamic Acid-d4
- CAS Number: 1246820-82-5
- Molecular Formula: C14H8D4ClNO2
- Molecular Weight: 265.728
- Catalog: Signaling Pathways Immunology/Inflammation COX
- Create Date: 2021-04-15 17:08:32
- Modify Date: 2024-04-08 19:19:08
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Tolfenamic Acid-D4 (GEA 6414-D4) is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1[1][2].
| Name | Tolfenamic Acid-d4 |
|---|---|
| Synonyms |
2-[(3-Chloro-2-methylphenyl)amino](2H4)benzoic acid
Benzoic-2,3,4,5-d4 acid, 6-[(3-chloro-2-methylphenyl)amino]- Tolfenamic Acid-d4 |
| Description | Tolfenamic Acid-D4 (GEA 6414-D4) is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 405.4±40.0 °C at 760 mmHg |
| Molecular Formula | C14H8D4ClNO2 |
| Molecular Weight | 265.728 |
| Flash Point | 199.0±27.3 °C |
| Exact Mass | 265.080750 |
| LogP | 5.76 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.658 |