1318025-77-2

1318025-77-2 structure

Name: Chevalone C
Chemical Name: Chevalone C
CAS Number: 1318025-77-2
Molecular Formula: C₂₈H₄₀O₅
Molecular Weight: 456.614
Catalog: Research Areas Cancer
Create Date: 2021-06-10 10:33:28
Modify Date: 2024-02-24 17:05:41
Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC50 value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines[1][2].

Name	Chevalone C
Synonyms	1H,11H-Phenanthro[2,1-b]pyrano[3,2-e]pyran-11-one, 2-(acetyloxy)-2,3,4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-tetradecahydro-1,1,4a,6a,9,12b-hexamethyl-, (2S,4aR,4bR,6aS,12aS,12bR,14aR)- (2S,4aR,4bR,6aS,12aS,12bR,14aR)-1,1,4a,6a,9,12b-Hexamethyl-11-oxo-2,3,4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-tetradecahydro-1H,11H-naphtho[2,1-f]pyrano[2,3-b]chromen-2-yl acetate Chevalone C

Description	Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC50 value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection
In Vitro	Chevalone C (1, 10, 50, 100, 200 μM; 24 hours) exhibits a significant decrease of cell viability in HepG2, HCT116 and HT29 cell lines (ic50=153 μM, 190 μM, 98 μM)[2].
References	[1]. Sasiphimol Sawadsitang, et al. Antimalarial and cytotoxic constituents of Xylaria cf. cubensis PK108. Nat Prod Res. 2015;29(21):2033-6. [2]. M Prata-Sena, et al. Cytotoxic activity of Secondary Metabolites from Marine-derived Fungus Neosartorya siamensis in Human Cancer Cells. Phytother Res. 2016 Nov;30(11):1862-1871.