1322625-54-6
1322625-54-6 structure
- Name: Lopinavir-d8
- Chemical Name: Lopinavir-d8
- CAS Number: 1322625-54-6
- Molecular Formula: C37H40D8N4O5
- Molecular Weight: 636.85
- Catalog: Research Areas Others
- Create Date: 2021-06-11 19:58:19
- Modify Date: 2024-01-14 11:31:43
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(rel)-Lopinavir-d8 ((rel)-ABT-378-d8)is the deuterium labeledLopinavir(HY-14588)[1]. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity[2][3]. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM[4].
| Name | Lopinavir-d8 |
|---|---|
| Synonyms |
N-[(2S,4S,5S)-5-{[(2,6-Dimethylphenoxy)acetyl]amino}-4-hydroxy-1,6-diphenyl-2-hexanyl]-3-(2H3)methyl-2-(2-oxotetrahydro-1(2H)-pyrimidinyl)(2H5)butanamide
1(2H)-Pyrimidineacetamide-d, N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-[1-(methyl-d3)ethyl-1,2,2,2-d4]-2-oxo- Lopinavir-d8 |
| Description | (rel)-Lopinavir-d8 ((rel)-ABT-378-d8)is the deuterium labeledLopinavir(HY-14588)[1]. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity[2][3]. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM[4]. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 924.2±65.0 °C at 760 mmHg |
| Molecular Formula | C37H40D8N4O5 |
| Molecular Weight | 636.85 |
| Flash Point | 512.7±34.3 °C |
| Exact Mass | 636.412659 |
| LogP | 6.26 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.577 |