1332184-63-0

1332184-63-0 structure

Name: IL-4-inhibitor-1
Chemical Name: IL-4 Inhibitor
CAS Number: 1332184-63-0
Molecular Formula: C₁₈H₁₂FN₃O₂
Molecular Weight: 321.31
Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
Create Date: 2021-06-13 06:49:59
Modify Date: 2024-01-11 15:36:30
IL-4-inhibitor-1 (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 µM[1].

Name	IL-4 Inhibitor
Synonyms	3-Pyridinecarbonitrile, 2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)- IL-4 Inhibitor 2-Amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)nicotinonitrile

Description	IL-4-inhibitor-1 (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 µM[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Target	EC50: 1.81 µM (IL-4)[1].
In Vitro	IL-4-inhibitor-1 (compound 52) displays low micromolar affinity and exhibits functional disruption of type II IL-4 binding in a cellular context[1]. IL-4-inhibitor-1 (compound 52) exhibits dose-dependent reduction in pSTAT-6 levels with an EC50 value of 3.1 µM, but did not affect the levels of STAT-6[1].
References	[1]. Sean P Quinnell, et al. A Small-Molecule Inhibitor to the Cytokine Interleukin-4. ACS Chem Biol. 2020 Oct 16;15(10):2649-2654.