139889-65-9

139889-65-9 structure

Name: D-threo-PPMP hydrochloride
Chemical Name: D-threo-PPMP (hydrochloride)
CAS Number: 139889-65-9
Molecular Formula: C₂₉H₅₁ClN₂O₃
Molecular Weight: 511.180
Catalog: Research Areas Neurological Disease
Create Date: 2021-06-18 18:20:34
Modify Date: 2024-01-09 13:00:36
D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP hydrochloride can block karyokinesis and reduce cyst production[1][2].

Name	D-threo-PPMP (hydrochloride)
Synonyms	DL-threo-PPMP (hydrochloride) N-[(1R,2R)-1-Hydroxy-3-(4-morpholinyl)-1-phenyl-2-propanyl]hexadecanamide hydrochloride (1:1) Hexadecanamide, N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1) D-threo-PPMP (hydrochloride)

Description	D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP hydrochloride can block karyokinesis and reduce cyst production[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	glucosylceramide synthase[1]
In Vitro	D-threo-PPMP (10 μM; 72 h) hydrochloride decreases the MDR1 expression by 70% in KB-V0.01 cells[1].
References	[1]. Gouazé V, et, al. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res. 2005 May 1;65(9):3861-7. [2]. Hernandez Y. Novel role of sphingolipid synthesis genes in regulating giardial encystation. Infect Immun. 2008 Jul;76(7):2939-49. [3]. Wu X, et, al. Liquid chromatography method for quantifying D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (D-threo-PPMP) in mouse plasma and liver. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6;837(1-2):44-8.