D-threo-PPMP hydrochloride

Modify Date: 2024-01-09 13:00:36

D-threo-PPMP hydrochloride Structure
D-threo-PPMP hydrochloride structure
Common Name D-threo-PPMP hydrochloride
CAS Number 139889-65-9 Molecular Weight 511.180
Density N/A Boiling Point N/A
Molecular Formula C29H51ClN2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of D-threo-PPMP hydrochloride


D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP hydrochloride can block karyokinesis and reduce cyst production[1][2].

 Names

Name D-threo-PPMP (hydrochloride)
Synonym More Synonyms

 D-threo-PPMP hydrochloride Biological Activity

Description D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP hydrochloride can block karyokinesis and reduce cyst production[1][2].
Related Catalog
Target

glucosylceramide synthase[1]

In Vitro D-threo-PPMP (10 μM; 72 h) hydrochloride decreases the MDR1 expression by 70% in KB-V0.01 cells[1].
References

[1]. Gouazé V, et, al. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res. 2005 May 1;65(9):3861-7.

[2]. Hernandez Y. Novel role of sphingolipid synthesis genes in regulating giardial encystation. Infect Immun. 2008 Jul;76(7):2939-49.

[3]. Wu X, et, al. Liquid chromatography method for quantifying D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (D-threo-PPMP) in mouse plasma and liver. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6;837(1-2):44-8.

 Chemical & Physical Properties

Molecular Formula C29H51ClN2O3
Molecular Weight 511.180
Exact Mass 510.358826

 Synonyms

DL-threo-PPMP (hydrochloride)
N-[(1R,2R)-1-Hydroxy-3-(4-morpholinyl)-1-phenyl-2-propanyl]hexadecanamide hydrochloride (1:1)
Hexadecanamide, N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1)
D-threo-PPMP (hydrochloride)