2320429-05-6

2320429-05-6 structure

Name: Coelenterazine 400a (hydrochloride)
Chemical Name: Coelenterazine 400a (hydrochloride)
CAS Number: 2320429-05-6
Molecular Formula: C₂₆H₂₂ClN₃O
Molecular Weight: 427.925
Catalog: Research Areas Others
Create Date: 2021-08-10 21:40:40
Modify Date: 2024-01-13 05:52:53
Coelenteramine 400a (Coelenterazine 400a) hydrochloride, a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a hydrochloride, RLuc can emit blue light at 395 nm[1][2]. Coelenteramine 400a hydrochloride will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenteramine 400a hydrochloride provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET)[3].

Name	Coelenterazine 400a (hydrochloride)
Synonyms	2,8-Dibenzyl-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one hydrochloride (1:1) Coelenterazine 400a (hydrochloride) Imidazo[1,2-a]pyrazin-3(7H)-one, 6-phenyl-2,8-bis(phenylmethyl)-, hydrochloride (1:1)

Description	Coelenteramine 400a (Coelenterazine 400a) hydrochloride, a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a hydrochloride, RLuc can emit blue light at 395 nm[1][2]. Coelenteramine 400a hydrochloride will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenteramine 400a hydrochloride provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET)[3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Levi J, et, al. Bisdeoxycoelenterazine derivatives for improvement of bioluminescence resonance energy transfer assays. J Am Chem Soc. 2007 Oct 3;129(39):11900-1. [2]. Bertrand L, et, al. The BRET2/arrestin assay in stable recombinant cells: a platform to screen for compounds that interact with G protein-coupled receptors (GPCRS). J Recept Signal Transduct Res. Feb-Nov 2002;22(1-4):533-41. [3]. Yuan M L, et al. Luminescence of coelenterazine derivatives with C-8 extended electronic conjugation[J]. Chinese Chemical Letters, 2016, 27(4): 550-554.