Coelenterazine 400a (hydrochloride)

Modify Date: 2024-01-13 05:52:53

Coelenterazine 400a (hydrochloride) structure	Common Name	Coelenterazine 400a (hydrochloride)
	CAS Number	2320429-05-6	Molecular Weight	427.925
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₂ClN₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Coelenterazine 400a (hydrochloride)

Coelenteramine 400a (Coelenterazine 400a) hydrochloride, a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a hydrochloride, RLuc can emit blue light at 395 nm[1][2]. Coelenteramine 400a hydrochloride will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenteramine 400a hydrochloride provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET)[3].

Name	Coelenterazine 400a (hydrochloride)
Synonym	More Synonyms

Description	Coelenteramine 400a (Coelenterazine 400a) hydrochloride, a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a hydrochloride, RLuc can emit blue light at 395 nm[1][2]. Coelenteramine 400a hydrochloride will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenteramine 400a hydrochloride provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET)[3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Levi J, et, al. Bisdeoxycoelenterazine derivatives for improvement of bioluminescence resonance energy transfer assays. J Am Chem Soc. 2007 Oct 3;129(39):11900-1. [2]. Bertrand L, et, al. The BRET2/arrestin assay in stable recombinant cells: a platform to screen for compounds that interact with G protein-coupled receptors (GPCRS). J Recept Signal Transduct Res. Feb-Nov 2002;22(1-4):533-41. [3]. Yuan M L, et al. Luminescence of coelenterazine derivatives with C-8 extended electronic conjugation[J]. Chinese Chemical Letters, 2016, 27(4): 550-554.

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Levi J, et, al. Bisdeoxycoelenterazine derivatives for improvement of bioluminescence resonance energy transfer assays. J Am Chem Soc. 2007 Oct 3;129(39):11900-1.

[2]. Bertrand L, et, al. The BRET2/arrestin assay in stable recombinant cells: a platform to screen for compounds that interact with G protein-coupled receptors (GPCRS). J Recept Signal Transduct Res. Feb-Nov 2002;22(1-4):533-41.

[3]. Yuan M L, et al. Luminescence of coelenterazine derivatives with C-8 extended electronic conjugation[J]. Chinese Chemical Letters, 2016, 27(4): 550-554.

Molecular Formula	C₂₆H₂₂ClN₃O
Molecular Weight	427.925
Exact Mass	427.145142

2,8-Dibenzyl-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one hydrochloride (1:1)

Coelenterazine 400a (hydrochloride)

Imidazo[1,2-a]pyrazin-3(7H)-one, 6-phenyl-2,8-bis(phenylmethyl)-, hydrochloride (1:1)

Coelenterazine 400a (hydrochloride)

Use of Coelenterazine 400a (hydrochloride)

Names

Coelenterazine 400a (hydrochloride) Biological Activity

Chemical & Physical Properties

Synonyms