6014-30-8

6014-30-8 structure

Name: Methyldopate
Chemical Name: Methyldopate
CAS Number: 6014-30-8
Molecular Formula: C₁₂H₁₇NO₄
Molecular Weight: 239.268
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2021-09-06 19:06:45
Modify Date: 2025-08-27 11:59:52
Methyldopate is an ethyl ester prodrug of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate has the potential for severe hypertension research [1].

Name	Methyldopate
Synonyms	Ethyl 3-hydroxy-α-methyl-L-tyrosinate Alanine, 3-(3,4-dihydroxyphenyl)-2-methyl-, ethyl ester, L- L-Methyldopa ethyl ester 3-Hydroxy-a-methyl-L-tyrosine Ethyl Ester MFCD00865839 L-3-(3,4-Dihydroxyphenyl)-2-methylalanine ethyl ester EINECS 219-720-3 2579Z4P04J L-Tyrosine, 3-hydroxy-α-methyl-, ethyl ester EINECS 219-821-2 Methyldopate L-Methyldopate

Description	Methyldopate is an ethyl ester prodrug of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate has the potential for severe hypertension research [1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
In Vivo	Methyldopate is hydrolysed in vivo to methyldopa[2].
References	[1]. P D Walson, et al. Metabolic disposition and cardiovascular effects of methyldopate in unanesthetized rhesus monkeys. J Pharmacol Exp Ther. 1975 Oct;195(1):151-8. [2]. Hoskins JA, et al. Determination of alpha-methyldopa and methyldopate in human breast milk and plasma by ion-exchange chromatography using electrochemical detection. J Chromatogr. 1982 Jun 11;230(1):162-7.