917091-74-8

917091-74-8 structure

Name: Globosuxanthone A
Chemical Name: Globosuxanthone A
CAS Number: 917091-74-8
Molecular Formula: C₁₅H₁₂O₇
Molecular Weight: 304.252
Create Date: 2021-09-18 20:40:34
Modify Date: 2024-01-05 15:36:33
Globosuxanthone A is a dihydroxanthenone with obvious antifungal activity towards Fusarium graminearum, Fusarium solani, and Botrytis cinerea with MIC values of 4, 8, and 16 μg/mL, respectively. Anticancer activity[1][2].

Name	Globosuxanthone A
Synonyms	globosuxanthone A Methyl (1R,2R)-1,2,8-trihydroxy-9-oxo-2,9-dihydro-1H-xanthene-1-carboxylate 1H-Xanthene-1-carboxylic acid, 2,9-dihydro-1,2,8-trihydroxy-9-oxo-, methyl ester, (1R,2R)-

Description	Globosuxanthone A is a dihydroxanthenone with obvious antifungal activity towards Fusarium graminearum, Fusarium solani, and Botrytis cinerea with MIC values of 4, 8, and 16 μg/mL, respectively. Anticancer activity[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Globosuxanthone A shows cytotoxicities against NCI-H460, MCF-7, SF-268, PC-3, PC-3M, LNCaP, DU-145 cells (IC50=0.65-3.6 µM)[1]. Globosuxanthone A impairs cell cycle progression of NCI-H460 and PC-3M cells leading to accumulation in the G2/M and S phases [1].
References	[1]. Miao C, et al. Antifungal xanthones produced by the endophytic fungus Paraconionthyrium sp. YM 311593. Folia Microbiol (Praha). 2020;65(3):567-572. [2]. Wijeratne EM, et al. A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity. Bioorg Med Chem. 2006;14(23):7917-7923.