2070014-87-6

2070014-87-6 structure

Name: MRT68921 hydrochloride
Chemical Name: MRT68921 hydrochloride
CAS Number: 2070014-87-6
Molecular Formula: C₂₅H₃₅ClN₆O
Molecular Weight: 471.038
Catalog: Signaling Pathways Autophagy ULK
Create Date: 2021-10-05 11:23:29
Modify Date: 2025-09-10 09:01:00
MRT68921 hydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively.

Name	MRT68921 hydrochloride
Synonyms	Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-, hydrochloride (1:1) N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide hydrochloride (1:1) MFCD30187515 BS-16452

Description	MRT68921 hydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> ULK
References	[1]. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83.