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220701-06-4

220701-06-4 structure
220701-06-4 structure
  • Name: Fmoc-Ala-Glu-Asn-Lys-NH2
  • Chemical Name: Fmoc-Ala-Glu-Asn-Lys-NH2
  • CAS Number: 220701-06-4
  • Molecular Formula: C33H43N7O9
  • Molecular Weight: 681.74
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2021-09-11 13:20:00
  • Modify Date: 2024-01-12 17:28:40
  • Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].

Name Fmoc-Ala-Glu-Asn-Lys-NH2
Description Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].
Related Catalog
In Vitro Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].
References

[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.

Molecular Formula C33H43N7O9
Molecular Weight 681.74