23982-76-5

23982-76-5 structure

Name: 10-Cl-BBQ
Chemical Name: 10-Cl-BBQ
CAS Number: 23982-76-5
Molecular Formula: C₁₈H₉ClN₂O
Molecular Weight: 304.73
Catalog: Signaling Pathways Immunology/Inflammation Aryl Hydrocarbon Receptor
Create Date: 2021-09-14 20:25:55
Modify Date: 2024-01-14 07:12:51
10-Cl-BBQ is a high affinity AhR ligand with immunosuppressive activity. 10-Cl-BBQ promotes cytosol to nuclear translocation of AhR and activates the AhR-regulated reporter gene at nanomolar concentrations[1][2].

Name	10-Cl-BBQ
Synonyms	10-chloro-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one 10-Chloro-7H-benzimidazo[2,1-a]benzo[de]isoquinolin-7-one 7H-Benzimidazo[2,1-a]benz[de]isoquinolin-7-one, 10-chloro- 7H-[1,3]Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one, 10-chloro- 10-Cl-BBQ

Description	10-Cl-BBQ is a high affinity AhR ligand with immunosuppressive activity. 10-Cl-BBQ promotes cytosol to nuclear translocation of AhR and activates the AhR-regulated reporter gene at nanomolar concentrations[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor Research Areas >> Inflammation/Immunology
References	[1]. Sumit Punj, et al. Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One. 2014 Feb 19;9(2):e88726. [2]. Allison K Ehrlich, et al. Activation of the Aryl Hydrocarbon Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3+ Regulatory T Cells in Nonobese Diabetic Mice. J Immunol. 2016 Jan 1;196(1):264-73.