1422252-46-7
1422252-46-7 structure
- Name: BI-9627 hydrochloride
- Chemical Name: BI-9627 hydrochloride
- CAS Number: 1422252-46-7
- Molecular Formula: C16H20ClF3N4O2
- Molecular Weight: 392.80
- Create Date: 2021-09-19 19:42:44
- Modify Date: 2024-01-10 21:28:40
-
BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (drug-drug interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.
| Name | BI-9627 hydrochloride |
|---|
| Description | BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (drug-drug interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury. |
|---|
| Molecular Formula | C16H20ClF3N4O2 |
|---|---|
| Molecular Weight | 392.80 |