145563-68-4

145563-68-4 structure

Name: Rovunaptabin
Chemical Name: thrombin aptamer
CAS Number: 145563-68-4
Molecular Formula: C₁₅₀H₁₈₇N₅₇O₁₀₃P₁₄
Molecular Weight: 4870.0
Catalog: Signaling Pathways Metabolic Enzyme/Protease Thrombin
Create Date: 2021-09-11 16:57:20
Modify Date: 2026-07-10 18:37:25
Rovunaptabin (ARC 183) is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity.

Name	thrombin aptamer

Description	Rovunaptabin (ARC 183) is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin Research Areas >> Others
References	[1]. Bompiani KM, Monroe DM, Church FC, Sullenger BA. A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity. J Thromb Haemost. 2012;10(5):870-880. [2]. Bonifacio L, Church FC, Jarstfer MB. Effect of locked-nucleic acid on a biologically active g-quadruplex. A structure-activity relationship of the thrombin aptamer. Int J Mol Sci. 2008;9(3):422-433.