1264-72-8
1264-72-8 structure
- Name: Colistin sulfate
- Chemical Name: Colistin Sulfate
- CAS Number: 1264-72-8
- Molecular Formula: C52H100N16O17S
- Molecular Weight: 1253.51
- Catalog: API Antibiotics Other antibiotics
- Create Date: 2018-02-08 08:00:00
- Modify Date: 2026-07-06 08:06:53
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Colistin is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.
| Name | Colistin Sulfate |
|---|---|
| Synonyms |
Polymyxin E
Polymyxin E colistinsulfat Colistin Sulphate N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-htaoxo-1,4,7,10,13,16,19-htazacyclotricos-21-yl]cbamoyl]propyl]cbamoyl]-2-hydroxy-propyl]cbamoyl]propyl]-5-methyl-htanamide sulfate Colistin sulfate (1-7 free base) colimycinsulfate COLISTIN SULFATE polymyxinesulfate(salt) Colistin sulfate salt,PolymyxinE Colistin sulfate for microbiological assay (C2700000) Belcomycine COLISTIN SULPHATE COLISTIN SULPHATE ADE Colstin sulfate (R)-N-((S)-4-Amino-1-(((2S,3R)-1-(((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-((R)-1-hydroxyethyl)-12,15-diisobutyl-2,5,8,11,14,17,20-htaoxo-1,4,7,10,13,16,19-htaazacyclotricosan-21-yl)amino)butan-2-yl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)-6-methyloctanamide sulfate Colistin Sulfate (mixture) > Colistin (sulfate) COLISTINSULFATE,POWDER Colistin sulfate ade) COLISTINE SULFATE Colistin sulfate salt,Polymyxin E Product Name:Colistin sulfate EINECS 215-034-3 Colistin Sulphate (CLS) Colistin sulfate salt COLISTINSULFATEE POLYMYXIN E belcomycin polymyxine Multimycine COLISTINE SULPHATE CoL Colistin Sulfate W.S.P Colistin sulphateQ: What is Colistin sulphate Q: What is the CAS Number of Colistin sulphate Q: What is the storage condition of Colistin sulphate Q: What e the applications of Colistin sulphate Colistin sulphate(Colistin sulfate) Colistine Sulphate/Colistin sulfate POLYMYXIN E SULFATE Polymyxin(Colistin Sulfate) ColistinSulfate5 Polymixin E Sulfate Colistin sulfate, 00 IU/Mg Colistin Sulfate (COS, cGMP) liusuanlianjunsu Colistin sulfate for microbiological assay CRS (R)-N-((S)-4-Amino-1-(((2S,3R)-1-(((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-((R)-1-hydroxyethyl)-12,15-diisobutyl-2,5,8,11,14,17,20-htaoxo-1,4,7,10,13,16,19-htaazacyclotricosan-21-yl)amino)butan-2-yl)amino)-3-hydrox Colistin sulfate //BP MFCD00146495 Animal Feed Additives colistin sulfate Colistin Sulfate Colistin sulfate, nonsterile Polymixin E colomycinsyrup N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-htaoxo-1,4,7,10,13,16,19-htazacyclotricos-21-yl]amino]butan-2-yl]amino istin suL Colimycin E sulfate Colistin Sulfate COS COLISTIN SULFATE SALT Colistin Sulfate (mixture) Colomyci Colistin sulphate premix Colistin sulfa |
| Description | Colistin is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria. |
|---|---|
| Related Catalog | |
| In Vitro | Colistins are bactericidal to gram-negative bacteria by a detergent-like mechanism. This mechanism involves interaction with lipopolysaccharides and phospholipids of the outer membrane and electrostatic interference with the outer membrane by competitively displacing divalent cations (calcium and magnesium) from the negatively charged phosphate groups of membrane lipids[1]. Colistin (polymyxin E) owns favorable properties of rapid bacterial killing, a narrow spectrum of activity, and an associated slow development of resistance for the treatment of infections caused by multidrug-resistant gram-negative bacteria. There are two forms of colistin available commercially: colistin (sulfate) mainly for topical use and colistin methanesulfonate (sodium) for parenteral use[2]. |
| In Vivo | High concentrations of colistin in rat ELF are achieved as a result of slow and sustained CMS conversion following i.t. instillation[3]. Colistin is often used in piglets but underdosing and overdosing are frequent. Under- or overdoses of colistin do not result in any major disturbance of piglet fecal microbiota and rarely select for chromosomal resistance in the dominant E. coli population[4]. |
| Animal Admin | Rats: Colistin methanesulfonate (sodium) and colistin (sulfate) dosing solutions are freshly prepared in sterile 0.9% sodium chloride. For the i.v. studies, colistin methanesulfonate (CMS) or sulfate solutions are administered by a bolus injection via the jugular vein cannula. Intratracheal (i.t.) instillation is utilized as the technique for pulmonary administration. Animals are administered i.v. CMS at doses of 14 mg/kg of body weight, 28 mg/kg or 56 mg/kg. In an independent study, rats are administered i.v. colistin at doses of 0.21 mg/kg, 0.41 mg/kg, or 0.62 mg/kg[3]. |
| References |
[1]. Hancock RE et al. Peptide antibiotics. Antimicrob Agents Chemother. 1999 Jun;43(6):1317-23. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 1537.3±65.0 °C at 760 mmHg |
| Melting Point | 200-220°C |
| Molecular Formula | C52H100N16O17S |
| Molecular Weight | 1253.51 |
| Flash Point | 883.5±34.3 °C |
| PSA | 573.64000 |
| LogP | -3.68 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.575 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | Missing Phrase - N15.00950417 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic |
| Risk Phrases | R25 |
| Safety Phrases | S45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | TR1500000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2309901000 |
| HS Code | 2309901000 |
|---|