Name | pyrazinecarboxamide |
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Synonyms |
5-25-04-00178 (Beilstein Handbook Reference)
Pyrafat 2-Pyrazinecarboxamide 2-(Aminocarbonyl)pyrazine pyrazinamide Aldinamide Zinamide a-Pyrazinamide pyrazinoic acid amide Tebrazid Aldinamid MFCD00006132 pyrazinecarboxylic acid amide Pyrazinecarboxamide EINECS 202-717-6 Rifater Pyrazinamide (TN) pyrazine-2-carboxamide pyrazine-2-carboxylic acid amide |
Description | Pyrazinamide is a pyrazine that is used therapeutically as an antitubercular agent.Target: AntibacterialPyrazinamide is a prodrug that stops the growth of Mycobacterium tuberculosis. Pyrazinoic acid was thought to inhibit the enzyme fatty acid synthase (FAS) I, which is required by the bacterium to synthesise fatty acids although this has been discounted. It was also suggested that the accumulation of pyrazinoic acid disrupts membrane potential and interferes with energy production, necessary for survival of M. tuberculosis at an acidic site of infection. Pyrazinoic acid binds to the ribosomal protein S1 (RpsA) and inhibits trans-translation. This may explain the ability of the drug to kill dormant mycobacteria [1-4]. |
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Related Catalog | |
References |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 273.3±43.0 °C at 760 mmHg |
Melting Point | 189-191 °C(lit.) |
Molecular Formula | C5H5N3O |
Molecular Weight | 123.113 |
Flash Point | 119.1±28.2 °C |
Exact Mass | 123.043259 |
PSA | 68.87000 |
LogP | -0.83 |
Vapour Pressure | 0.0±0.6 mmHg at 25°C |
Index of Refraction | 1.648 |
Storage condition | -20°C Freezer |
Water Solubility | 15 mg/mL |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | F: Flammable;C: Corrosive; |
Risk Phrases | R11 |
Safety Phrases | S22-S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | UQ2275000 |
HS Code | 2933599090 |
Precursor 10 | |
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DownStream 10 | |
HS Code | 2934999090 |
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Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |