370073-65-7

370073-65-7 structure

Name: 2-(4-FLUOROPHENYLAMINO)THIAZOLO[4,5-B]PYRIDINE-5,7-DIOL
Chemical Name: 2-[(4-Fluorophenyl)amino]-7-hydroxy[1,3]thiazolo[4,5-b]pyridin-5(4H)-one
CAS Number: 370073-65-7
Molecular Formula: C₁₂H₈FN₃O₂S
Molecular Weight: 277.274
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2021-09-11 14:26:34
Modify Date: 2024-04-08 17:48:08
STK683963 is a strong activator of cellular ATG4B activity. STK683963 can act as a mediator of redox-regulation of ATG4B in cells. STK683963 can be used for the research of cancer[1].

Name	2-[(4-Fluorophenyl)amino]-7-hydroxy[1,3]thiazolo[4,5-b]pyridin-5(4H)-one
Synonyms	2-[(4-Fluorophenyl)amino]-7-hydroxy[1,3]thiazolo[4,5-b]pyridin-5(4H)-one MFCD01242898 Thiazolo[4,5-b]pyridin-5(4H)-one, 2-[(4-fluorophenyl)amino]-7-hydroxy-

Description	STK683963 is a strong activator of cellular ATG4B activity. STK683963 can act as a mediator of redox-regulation of ATG4B in cells. STK683963 can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
In Vitro	STK683963 (0-50 μM) 在 24 小时后以剂量依赖性方式强烈上调荧光素酶释放报告基因[1]。 STK683963 强烈激活荧光素酶释放，这在 NAC 存在下被完全阻断[1]。
References	[1]. Niccolo Pengo, et al. Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells. Front Cell Dev Biol. 2018 Nov 1;6:148.