2-(4-FLUOROPHENYLAMINO)THIAZOLO[4,5-B]PYRIDINE-5,7-DIOL

Modify Date: 2024-04-08 17:48:08

2-(4-FLUOROPHENYLAMINO)THIAZOLO[4,5-B]PYRIDINE-5,7-DIOL Structure
2-(4-FLUOROPHENYLAMINO)THIAZOLO[4,5-B]PYRIDINE-5,7-DIOL structure
Common Name 2-(4-FLUOROPHENYLAMINO)THIAZOLO[4,5-B]PYRIDINE-5,7-DIOL
CAS Number 370073-65-7 Molecular Weight 277.274
Density 1.7±0.1 g/cm3 Boiling Point 554.2±60.0 °C at 760 mmHg
Molecular Formula C12H8FN3O2S Melting Point N/A
MSDS N/A Flash Point 289.0±32.9 °C

 Use of 2-(4-FLUOROPHENYLAMINO)THIAZOLO[4,5-B]PYRIDINE-5,7-DIOL


STK683963 is a strong activator of cellular ATG4B activity. STK683963 can act as a mediator of redox-regulation of ATG4B in cells. STK683963 can be used for the research of cancer[1].

 Names

Name 2-[(4-Fluorophenyl)amino]-7-hydroxy[1,3]thiazolo[4,5-b]pyridin-5(4H)-one
Synonym More Synonyms

  Biological Activity

Description STK683963 is a strong activator of cellular ATG4B activity. STK683963 can act as a mediator of redox-regulation of ATG4B in cells. STK683963 can be used for the research of cancer[1].
Related Catalog
In Vitro STK683963 (0-50 μM) 在 24 小时后以剂量依赖性方式强烈上调荧光素酶释放报告基因[1]。 STK683963 强烈激活荧光素酶释放,这在 NAC 存在下被完全阻断[1]。
References

[1]. Niccolo Pengo, et al. Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells. Front Cell Dev Biol. 2018 Nov 1;6:148.  

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 554.2±60.0 °C at 760 mmHg
Molecular Formula C12H8FN3O2S
Molecular Weight 277.274
Flash Point 289.0±32.9 °C
Exact Mass 277.032135
LogP 3.30
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.809

 Synonyms

2-[(4-Fluorophenyl)amino]-7-hydroxy[1,3]thiazolo[4,5-b]pyridin-5(4H)-one
MFCD01242898
Thiazolo[4,5-b]pyridin-5(4H)-one, 2-[(4-fluorophenyl)amino]-7-hydroxy-