Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID
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Purity: 98.0%
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844639-57-2

844639-57-2 structure

Name: CAY10471 Racemate
Chemical Name: 9H-Carbazole-9-acetic acid, 3-[[(4-fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro
CAS Number: 844639-57-2
Molecular Formula: C₂₁H₂₁FN₂O₄S
Molecular Weight: 416.46600
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2016-02-14 09:48:14
Modify Date: 2024-01-03 17:21:21
CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandin D2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM). CAY10471 Racemate also has effect on mouse and rat orthologs of CRTH2[1].

Name	9H-Carbazole-9-acetic acid, 3-[[(4-fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro
Synonyms	3-[[(4-fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro-9h-carbazole-9-acetic acid

Description	CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandin D2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM). CAY10471 Racemate also has effect on mouse and rat orthologs of CRTH2[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Target	Ki: 0.6 nM (CRTH2), 200 nM (DP)[1]
In Vitro	CAY10471 Racemate (Compound 13) inhibits PGD2-induced inositol phosphate or cAMP formatio, suppresses β-arrestin translocation with IC50s of 12 and 3 nM, respectively[1].
References	[1]. Ulven T, et al. Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J Med Chem. 2005 Feb 24;48(4):897-900.