Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Isosorbide 5-mononitrate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Isosorbide 5-mononitrate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

16051-77-7

16051-77-7 structure

Name: Isosorbide 5-mononitrate
Chemical Name: isosorbide mononitrate
CAS Number: 16051-77-7
Molecular Formula: C₆H₉NO₆
Molecular Weight: 191.139
Catalog: API Circulatory system medication Prevention and treatment of angina pectoris
Create Date: 2018-08-29 19:48:35
Modify Date: 2026-06-30 21:20:18
Isosorbide mononitrate(Isosorbide-5-mononitrate) is a nitrate-class compound used for angina pectoris; acts by dilating the blood vessels so as to reduce the blood pressure.

Name	isosorbide mononitrate
Synonyms	Monicor 1,4:3,6-dianhydro-d-glucitol5-nitrate 6-Nitrooxy-hexahydro-furo[3,2-β]furan-3-ol 8-Nitrooxy-2,6-dioxabicyclo[3.3.0]octan-4-ol 1,4:3,6-Dianhydro-5-O-nitro-D-glucitol Elantan MONOKET [(3R,3aS,6S,6-6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl nitrate Imdur Mono-Mack Corangin MONOSORB bm22-145 IMDUR CORANGIN Monosorb ELANTAN Monoket isosorbide nitrate (3R,3aS,6S,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl nitrate IS-5-MN ISOSORBIDE 5-MONONITRATE 1,4:3,6-Dianhydro-D-glucitol 5-nitrate [(1R,2R,5R,6S)-6-hydroxy-4,8-dioxabicyclo[3.3.0]oct-2-yl] nitrate Pentacard Monoclair Isosorbide 5-Nitrate MONOCEDOCD 5-Nitro-1,4,3,6-dianhydro-D-glucitol Corangin,Elan,Elantan,Imdur,Monocedocd,Monoclair,Monosorb (3S,3aS,6R,6-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl nitrate IS-5-MN (ISOSORBIDE-5-MONONITRATE 1,4:3,6-dianhydro-,5-nitrate,d-glucito 6-Nitroxoyhexahydrofuro[3,2-b]furan-3-ol EINECS 240-197-2 ISOSORBIDE MONO ACETATE Isomonat elan Isosorbide Mononitrate D-Glucitol, 1,4:3,6-dianhydro-, 5-nitrate 1,4:3,6-DIANHYDRO-D-GLUCITOL 5-MONONITRATE 6-Nitrooxy-hexahydro-furo[3,2-b]furan-3-ol 5-ISOSORBIDE MONONITRATE MONOCLAIR ISOSORBIDE MONONITRATE(ISOSORBIDE-5-MONONITRATE) Isosorbide 5-Mononitrate (1.0 mg/mL in Dimethyl Sulfoxide) Ososoribide-5-mononitrate 1,4:3,6-dianhydro-D-glucitol-5-nitrate ISOSORBIDE 5-NITRATE nitrate de (3R,3aS,6S,6aR)-6-hydroxyhexahydrofuro[3,2-b]fur-3-yle Diluted Isosorbide Mononitrate Momt Ismo isosorbide-5-mononitrate Olicard Isosorbide5-Nitrate> Erlotinib-d17 HCl ahr4698 Isosorbide mononitrate CRS 1,4:3,6-Dianhydro-D-glucitol mononitrate 1,4:3,6-dianhydro-d-glucito5-nitrate Olicd Monit ISMN MFCD00143462 TY-10368 Vasotrate Isosorbide-5-mononitrate min (3R,3aS,6S,6-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl nitrate Coronu (3R,3aS,6S,6aR)-6-Hydroxyhexahydrofuro[3,2-b]fur-3-ylnitrat Isosorbide mononitrate,contains ~(w/w) lactose 1,4:3,6-Dianhydro-D-glucitd 5-mononitrate isosorbide 5-mononitrite 1,4:3,6-Dianhydro-5-O-nitro-D-erythro-hexitol 5-ismn

Description	Isosorbide mononitrate(Isosorbide-5-mononitrate) is a nitrate-class compound used for angina pectoris; acts by dilating the blood vessels so as to reduce the blood pressure.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cardiovascular Disease

Density	1.6±0.1 g/cm3
Boiling Point	364.5±42.0 °C at 760 mmHg
Melting Point	88-93 °C
Molecular Formula	C₆H₉NO₆
Molecular Weight	191.139
Flash Point	174.2±27.9 °C
Exact Mass	191.042984
PSA	93.74000
LogP	-0.51
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.543
Water Solubility	soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ4386500

CAS REGISTRY NUMBER :: 16051-77-7

LAST UPDATED :: 199706

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C6-H9-N-O6

MOLECULAR WEIGHT :: 191.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2010 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Kidney, Ureter, Bladder - urine volume increased Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 29,327,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1760 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - altered sleep time (including change in righting reflex) Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 29,327,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 29,327,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1771 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 128,74,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1810 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 29,327,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1820 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 29,327,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 147 gm/kg/26W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Endocrine - changes in spleen weight Blood - other changes

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,171,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 182 gm/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - other changes

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,1079,1985 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 91 gm/kg

SEX/DURATION :: male 91 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,1079,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 27 gm/kg

SEX/DURATION :: female 17-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,6911,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 27 gm/kg

SEX/DURATION :: female 17-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - physical Reproductive - Effects on Newborn - delayed effects

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,6911,1986

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 860 ug/m3

SEX/DURATION :: female 1-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - hepatobiliary system Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),28,1996

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 100 ug/m3

SEX/DURATION :: female 1-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - delayed effects

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),28,1996

Hazard Codes	F:Flammable
Risk Phrases	R11;R36/37/38
Safety Phrases	S37/39-S16-S15
RIDADR	3251
RTECS	LZ4386500
Packaging Group	III
Hazard Class	1.1A
HS Code	2932999099

Precursor 10
39813-48-4 87-33-2 56-23-5 75648-24-7
7664-93-9 79-31-2 652-67-5 13042-39-2
13042-38-1 84207-83-0
DownStream 0

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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1807236-41-4	1566719-90-1
1566977-24-9	1805104-40-8
1956318-32-3	1805665-37-5
1804575-17-4	1803925-42-9
1805318-96-0	1806019-34-0