204069-50-1

204069-50-1 structure

Name: RTI 4229-336
Chemical Name: RTI-336
CAS Number: 204069-50-1
Molecular Formula: C₂₄H₂₆Cl₂N₂O
Molecular Weight: 429.38
Create Date: 2021-09-10 19:11:34
Modify Date: 2024-03-02 22:02:18
RTI 336 is a phenyltropane analog, as well as a potent and selective dopamine transporter (DAT) inhibitor. RTI 336 inhibits addictive agent induced locomotor activity and self-administration in Lewis rats. RTI 336 exhibits inhibitory effects depending on inherent NAc DAT levels[1].

Name	RTI-336
Synonyms	(1R,2S,3S,5S)-3-(4-Chlorophenyl)-8-methyl-2-[3-(4-methylphenyl)-1,2-oxazol-5-yl]-8-azabicyclo[3.2.1]octane hydrochloride (1:1) 8-Azabicyclo[3.2.1]octane, 3-(4-chlorophenyl)-8-methyl-2-[3-(4-methylphenyl)-5-isoxazolyl]-, (1R,2S,3S,5S)-, hydrochloride (1:1) RTI-336

Description	RTI 336 is a phenyltropane analog, as well as a potent and selective dopamine transporter (DAT) inhibitor. RTI 336 inhibits addictive agent induced locomotor activity and self-administration in Lewis rats. RTI 336 exhibits inhibitory effects depending on inherent NAc DAT levels[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter Research Areas >> Neurological Disease
In Vivo	RTI 336（3 mg/kg；皮下注射；30 分钟预处理）显著减少 Lewis 大鼠对成瘾剂的输注次数[1]。 RTI 336（3 毫克/千克；腹腔注射；30 分钟预处理）降低 Lewis 大鼠中由成瘾剂诱导的反应率（杠杆按压/秒）[1]。
References	[1]. Haile CN, et al. Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter. Brain Res. 2005 Sep 7;1055(1-2):186-95.