4608-49-5

4608-49-5 structure

Name: Larixyl acetate
Chemical Name: larixyl acetate
CAS Number: 4608-49-5
Molecular Formula: C₂₂H₃₆O₃
Molecular Weight: 348.51900
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2018-09-10 17:36:20
Modify Date: 2025-09-05 13:18:39
Larixyl acetate is a potent and selective TRPC6 inhibitor with IC50 values of 0.58 μM and 6.83 μM against hTRPC6-YFP and hTRPC3-YFP, respectively. Larixyl acetate prevents HPV and is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction[1][2].

Name	larixyl acetate
Synonyms	Larixylacetat Larixol-monoacetat 6-Acetyllarixol

Description	Larixyl acetate is a potent and selective TRPC6 inhibitor with IC50 values of 0.58 μM and 6.83 μM against hTRPC6-YFP and hTRPC3-YFP, respectively. Larixyl acetate prevents HPV and is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Infection Research Areas >> Neurological Disease
Target	hTRPC6:0.58 μM (IC50) hTRPC3:6.83 μM (IC50)
References	[1]. Urban N, et al. Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor. Mol Pharmacol. 2016 Jan;89(1):197-213. [2]. Chen X, et al. The TRPC6 inhibitor, larixyl acetate, is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction. J Neuroinflammation. 2019 Jan 31;16(1):21.

RIDADR	NONH for all modes of transport