Larixyl acetate

Modify Date: 2024-01-04 13:21:01

Larixyl acetate Structure
Larixyl acetate structure
Common Name Larixyl acetate
CAS Number 4608-49-5 Molecular Weight 348.51900
Density 1.00±0.1 g/cm3 (20ºC 760 Torr) Boiling Point 419.3±28.0 °C
Molecular Formula C22H36O3 Melting Point 82ºC
MSDS Chinese USA Flash Point N/A

 Use of Larixyl acetate


Larixyl acetate is a potent and selective TRPC6 inhibitor with IC50 values of 0.58 μM and 6.83 μM against hTRPC6-YFP and hTRPC3-YFP, respectively. Larixyl acetate prevents HPV and is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction[1][2].

 Names

Name larixyl acetate
Synonym More Synonyms

 Larixyl acetate Biological Activity

Description Larixyl acetate is a potent and selective TRPC6 inhibitor with IC50 values of 0.58 μM and 6.83 μM against hTRPC6-YFP and hTRPC3-YFP, respectively. Larixyl acetate prevents HPV and is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction[1][2].
Related Catalog
Target

hTRPC6:0.58 μM (IC50)

hTRPC3:6.83 μM (IC50)

References

[1]. Urban N, et al. Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor. Mol Pharmacol. 2016 Jan;89(1):197-213.

[2]. Chen X, et al. The TRPC6 inhibitor, larixyl acetate, is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction. J Neuroinflammation. 2019 Jan 31;16(1):21.

 Chemical & Physical Properties

Density 1.00±0.1 g/cm3 (20ºC 760 Torr)
Boiling Point 419.3±28.0 °C
Melting Point 82ºC
Molecular Formula C22H36O3
Molecular Weight 348.51900
Exact Mass 348.26600
PSA 46.53000
LogP 5.04400
Index of Refraction 1.4826 (589.3 nm, 20℃)
Storage condition ?20°C

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

Larixylacetat
Larixol-monoacetat
6-Acetyllarixol