158859-98-4

158859-98-4 structure

Name: GR231118
Chemical Name: gr 231118
CAS Number: 158859-98-4
Molecular Formula: C₁₁₀H₁₇₀N₃₄O₂₄
Molecular Weight: 2352.74000
Catalog: Signaling Pathways GPCR/G Protein Neuropeptide Y Receptor
Create Date: 2016-03-14 19:25:42
Modify Date: 2026-07-01 11:18:30
GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8)[1].

Name	gr 231118
Synonyms	231118 1229U91, Neuroptide Y Antagonist, Ile-Glu-Pro-Dapa-Tyr-g-Leu-g-Tyr-NH2, cyclic (2,4μ)(2μ,4) diamide C110H170N34O24 H-Ile-Glu-Pro-Dapa-Tyr-g-Leu-g-Tyr-NH2 L-Tyrosinamide, L-isoleucyl-L-α-glutamyl-L-prolyl-3-amino-L-alanyl-L-tyrosyl-L-ginyl-L-leucyl-L-ginyl-, bimol. (2→4'),(2'→4)-dilactam Ile-Glu-Pro-Dapa-Tyr-g-Leu-g-Tyr-NH2, cyclic (2,4') (2',4) diaMide (Dapa : diaMinopropionic acid) NEUROPTIDE Y ANTAGONIST H-ILE-GLU-PRO-DAP-TYR-G-LEU-G-TYR-NH2 1229U91 Amide Bridge=Glu2-Dap4*,Dap4-Glu2 ILE-GLU-PRO-DAPA-TYR-G-LEU-G-TYR-NH2, CYCLIC (2,4') (2',4) DIAMIDE

Description	GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
References	[1]. E M Parker, et al. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur J Pharmacol [2]. Y Dumont, et al. [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol. 2000 Jan;129(1):37-46.