166038-00-2
166038-00-2 structure
- Name: BrBzGCp2
- Chemical Name: S-4-bromobenzylglutathione cyclopentyl diester
- CAS Number: 166038-00-2
- Molecular Formula: C32H46BrN6O12S2
- Molecular Weight: 850.77500
- Catalog: Research Areas Neurological Disease
- Create Date: 2017-01-18 09:19:58
- Modify Date: 2024-09-19 18:24:47
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BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity[1][2].
| Name | S-4-bromobenzylglutathione cyclopentyl diester |
|---|---|
| Synonyms | MFCD28976196 |
| Description | BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity[1][2]. |
|---|---|
| Related Catalog | |
| Target |
GC50: 4.23 μM (GLO1)[1]. |
| In Vivo | GLO1 inhibition by BrBzGCp2 increases center time in the OF test, without changing distance traveled. GLO1 inhibition increases MG (methylglyoxal) concentration, thus reducing anxiety-like behavior[2]. BrBzGCp2 pre-treatment decreases seizure duration[3]. BrBzGCp2 injection alleviates the level of anxiety in mice, and mice with less anxiety and fear were more likely to explore the unknown area, implying that inhibition of GLO1 activity mitigated anxiety levels[4]. BrBzGCp2 treatment restores the VPA-induced inhibition effect on GABAA receptor activation[4]. BrBzGCp2 significantly lowers the blood pressure and ameliorated endothelial dysfunction in diabetic mice[5]. Animal Model: Male CD-1 mice[2]. Dosage: 50 mg/kg. Administration: IP once (Two hours post-injection, mice were sacrificed, and brains were rapidly dissected and flash-frozen on dry ice. MG concentration was measured) Result: Allowed MG levels to accumulate for 2 hours |
| References |
| Density | 1.38g/cm3 |
|---|---|
| Boiling Point | 790.6ºC at 760 mmHg |
| Molecular Formula | C32H46BrN6O12S2 |
| Molecular Weight | 850.77500 |
| Flash Point | 431.9ºC |
| Exact Mass | 849.18000 |
| PSA | 357.24000 |
| LogP | 2.98700 |
| Vapour Pressure | 5.64E-25mmHg at 25°C |
| Index of Refraction | 1.596 |
| RIDADR | NONH for all modes of transport |
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