2369068-42-6

2369068-42-6 structure
2369068-42-6 structure
  • Name: Thalidomide-O-C2-acid
  • Chemical Name: Thalidomide-O-C2-acid
  • CAS Number: 2369068-42-6
  • Molecular Formula: C16H14N2O7
  • Molecular Weight: 346.29
  • Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
  • Create Date: 2021-09-11 12:25:08
  • Modify Date: 2024-01-13 19:51:12
  • Thalidomide-O-C2-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Name Thalidomide-O-C2-acid
Description Thalidomide-O-C2-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008.

Molecular Formula C16H14N2O7
Molecular Weight 346.29
Hazard Codes Xi