65113-67-9

65113-67-9 structure

Name: ACK
Chemical Name: H-Glu-Gly-Arg-chloromethylketone
CAS Number: 65113-67-9
Molecular Formula: C₁₄H₂₅ClN₆O₅
Molecular Weight: 392.83900
Catalog: Signaling Pathways Metabolic Enzyme/Protease PAI-1
Create Date: 2016-06-13 02:16:09
Modify Date: 2026-07-16 13:10:24
GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like serine protease urokinase-type plasminogen activator (uPA) inhibitor[1].

Name	H-Glu-Gly-Arg-chloromethylketone
Synonyms	H-Glu-Gly-g-chloromethylketone trifluoroacetate salt GGACK/H-Glu-Gly-g-CMK GGACK、H-Glu-Gly-g-chloromethylketone Glutamyl-Glycyl-ginine Chloromethyl Ketone（ginine impurity 18） glutamyl-glycyl-arginine chloromethyl ketone Glutamyl-Glycyl-ginine Chloromethyl Ketone (S)-4-Amino-5-((2-amino-2-oxoethyl)((S)-1-chloro-6-guanidino-2-oxohexan-3-yl)amino)-5-oxopentanoic acid (S)-4-amino-5-((2-(((S)-1-chloro-6-guanidino-2-oxohexan-3-yl)amino)-2-oxoethyl)amino)-5-oxopentanoic acid Glycinamide, L-α-glutamyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]

Description	GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like serine protease urokinase-type plasminogen activator (uPA) inhibitor[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1 Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer
References	[1]. S Sperl, et al. (4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5113-8.