2137975-93-8
2137975-93-8 structure
- Name: diABZI-C2-NH2
- Chemical Name: diABZI-C2-NH2
- CAS Number: 2137975-93-8
- Molecular Formula: C36H43N13O4
- Molecular Weight: 721.81
- Catalog: Signaling Pathways Immunology/Inflammation STING
- Create Date: 2021-09-12 07:18:14
- Modify Date: 2024-01-18 21:28:16
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diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist[1].
| Name | diABZI-C2-NH2 |
|---|
| Description | diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist[1]. |
|---|---|
| Related Catalog | |
| In Vitro | The author developed a linking strategy to synergize the effect of two symmetry-related amidobenzimidazole (ABZI)-based compounds to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function. Intravenous administration of a diABZI STING agonist to immunocompetent mice with established syngeneic colon tumours elicited strong anti-tumour activity, with complete and lasting regression of tumors[1]. diABZI-C2-NH2 is covalently immobilized on sepharose beads and is used to affinity-capture potential target proteins from a THP1 cell lysate[1]. |
| References |
| Molecular Formula | C36H43N13O4 |
|---|---|
| Molecular Weight | 721.81 |