diABZI-C2-NH2

Modify Date: 2024-01-18 21:28:16

diABZI-C2-NH2 structure	Common Name	diABZI-C2-NH2
	CAS Number	2137975-93-8	Molecular Weight	721.81
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₆H₄₃N₁₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of diABZI-C2-NH2

diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist[1].

Name	diABZI-C2-NH2

Description	diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> STING
In Vitro	The author developed a linking strategy to synergize the effect of two symmetry-related amidobenzimidazole (ABZI)-based compounds to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function. Intravenous administration of a diABZI STING agonist to immunocompetent mice with established syngeneic colon tumours elicited strong anti-tumour activity, with complete and lasting regression of tumors[1]. diABZI-C2-NH2 is covalently immobilized on sepharose beads and is used to affinity-capture potential target proteins from a THP1 cell lysate[1].
References	[1]. Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity [published correction appears in Nature. 2019 Jun;570(7761):E53]. Nature. 2018;564(7736):439-443.

Molecular Formula	C₃₆H₄₃N₁₃O₄
Molecular Weight	721.81

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