2252334-12-4

2252334-12-4 structure

Name: Epitinib succinate
Chemical Name: Epitinib succinate
CAS Number: 2252334-12-4
Molecular Formula: C₂₈H₃₂N₆O₆
Molecular Weight: 548.59
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2021-09-05 13:45:48
Modify Date: 2025-08-27 13:58:09
Epitinib succinate is an orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) designed for optimal brain penetration. Epitinib succinate can be used for the research of cancer[1][2].

Name	Epitinib succinate

Description	Epitinib succinate is an orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) designed for optimal brain penetration. Epitinib succinate can be used for the research of cancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR[2]
In Vitro	Epitinib succinate is an orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) designed for optimal brain penetration[1][2].
References	[1]. Zhou et al. The safety profile of a selective EGFR TKI epitinib (HMPL-813) in patients with advanced solid tumors and preliminary clinical efficacy in EGFRm+ NSCLC patients with brain metastasis. Journal of Clinical Oncology 2016 34:15_suppl, e20502-e20502 [2]. Zhou et al. Phase I study of the safety and pharmacokinetics of epitinib, an oral EGFR tyrosine kinase inhibitor, in patients with advanced solid tumors. Journal of Clinical Oncology 2013 31:15_suppl, e19042-e19042

Molecular Formula	C₂₈H₃₂N₆O₆
Molecular Weight	548.59