Shanghai Nianxing Industrial Co., Ltd
China
Product Name: FNC-TP
Price: Check
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: FNC-TP
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

2457357-99-0

2457357-99-0 structure

2457357-99-0 structure

Name: FNC-TP
Chemical Name: FNC-TP
CAS Number: 2457357-99-0
Molecular Formula: C₉H₁₄FN₆O₁₃P₃
Molecular Weight: 526.16
Catalog: Signaling Pathways Anti-infection HBV
Create Date: 2021-09-14 17:37:13
Modify Date: 2025-08-21 17:53:53
FNC-TP is the intracellular active form of FNC. FNC is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV[1].

Name	FNC-TP

Description	FNC-TP is the intracellular active form of FNC. FNC is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV Signaling Pathways >> Anti-infection >> Reverse Transcriptase
Target	reverse transcriptase[1] HIV[1] HBV[1] HCV[1]
In Vitro	FNC (0.1-10 nM; 24-240 h) is found mainly to accumulate in these HIV-1 target cells, and the retention of FNC-TP is 2-4 times higher than in other types of cells[1].
In Vivo	FNC (1-6 mg/kg; a single p.o.) could enter rhesus macaque PBMCs and form the active nucleoside triphosphate FNC-TP[1].
References	[1]. Sun L, et, al. Mechanistic Insight into Antiretroviral Potency of 2'-Deoxy-2'-β-fluoro-4'-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention. J Med Chem. 2020 Aug 13;63(15):8554-8566.

Molecular Formula	C₉H₁₄FN₆O₁₃P₃
Molecular Weight	526.16

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