FNC-TP

Modify Date: 2025-08-21 17:53:53

FNC-TP Structure
FNC-TP structure
Common Name FNC-TP
CAS Number 2457357-99-0 Molecular Weight 526.16
Density N/A Boiling Point N/A
Molecular Formula C9H14FN6O13P3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FNC-TP


FNC-TP is the intracellular active form of FNC. FNC is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV[1].

 Names

Name FNC-TP

 FNC-TP Biological Activity

Description FNC-TP is the intracellular active form of FNC. FNC is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV[1].
Related Catalog
Target

reverse transcriptase[1] HIV[1] HBV[1] HCV[1]

In Vitro FNC (0.1-10 nM; 24-240 h) is found mainly to accumulate in these HIV-1 target cells, and the retention of FNC-TP is 2-4 times higher than in other types of cells[1].
In Vivo FNC (1-6 mg/kg; a single p.o.) could enter rhesus macaque PBMCs and form the active nucleoside triphosphate FNC-TP[1].
References

[1]. Sun L, et, al. Mechanistic Insight into Antiretroviral Potency of 2'-Deoxy-2'-β-fluoro-4'-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention. J Med Chem. 2020 Aug 13;63(15):8554-8566.

 Chemical & Physical Properties

Molecular Formula C9H14FN6O13P3
Molecular Weight 526.16
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