516478-09-4
516478-09-4 structure
- Name: iHCK-37
- Chemical Name: iHCK-37
- CAS Number: 516478-09-4
- Molecular Formula: C30H32N4O2S2
- Molecular Weight: 544.73
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Src
- Create Date: 2021-09-05 22:39:49
- Modify Date: 2024-01-16 12:53:55
-
iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a Ki value of 0.22 μM. iHCK-37 blocks HIV-1 viral replication with an EC50 value of 12.9 μM. iHCK-37 is used for chronic myeloid leukemia (CML) research[1].
| Name | iHCK-37 |
|---|
| Description | iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a Ki value of 0.22 μM. iHCK-37 blocks HIV-1 viral replication with an EC50 value of 12.9 μM. iHCK-37 is used for chronic myeloid leukemia (CML) research[1]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 0.22 μM (Hck)[1] |
| In Vitro | iHCK-37 (5.0-20 μM; 24 hours) exhibits a potent in vitro antiproliferative activity. The dose (μM) for growth inhibition (GI50) is 5.0-5.8 μM for AML cell lines (HL60, KG1a and U937) and 9.1-19.2 μM for chronic myeloid leukemia cell lines (HEL and K562)[2]. iHCK-37 (3-9 μM; plus Erythropoietin) leads to a decrease in ERK, AKT and P70S6K phosphorylation of in lentivirus HCK silenced K562 and U937 cell lines[2]. iHCK-37 (3-9 μM) results in a decrease of p-HCK, p-ERK, p-AKT, p-70S6 in the cell line KG1a (AML/CD34+), in a dose-dependent manner[2]. Cell Viability Assay[1] Cell Line: U937, HL60, KG1a, HEL and K562 cells Concentration: 5.0-20 μM Incubation Time: 24 hours Result: Exhibited a reduction of growth in a dose-dependent manner. |
| References |
| Molecular Formula | C30H32N4O2S2 |
|---|---|
| Molecular Weight | 544.73 |
| Storage condition | -20°C |