1010100-26-1

1010100-26-1 structure

Name: Lenalidomide-5-Br
Chemical Name: Lenalidomide-5-Br
CAS Number: 1010100-26-1
Molecular Formula: C₁₃H₁₁BrN₂O₃
Molecular Weight: 323.14
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2021-09-14 01:06:44
Modify Date: 2024-01-06 18:58:10
Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC[1].

Name	Lenalidomide-5-Br
Synonyms	3-(5-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Description	Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.