Shanghai Nianxing Industrial Co., Ltd
China
Product Name: NVS-PI3-4
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: NVS-PI3-4
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

941580-60-5

941580-60-5 structure

941580-60-5 structure

Name: NVS-PI3-4
Chemical Name: NVS-PI3-4
CAS Number: 941580-60-5
Molecular Formula: C₂₀H₂₆N₄O₃S
Molecular Weight: 402.51
Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
Create Date: 2021-09-13 11:45:26
Modify Date: 2024-01-16 09:25:51
NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases[1][2].

Name	NVS-PI3-4

Description	NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Research Areas >> Inflammation/Immunology
Target	PI3Kγ
In Vitro	NVS-PI3-4 shows an exquisite cellular selectivity for PI3Kγ. NVS-PI3-4 reduces IgE/antigen-mediated phosphorylation of PKB/Akt in p110δDA. NVS-PI3-4 (5 μM; 30 minutes; BMMCs) is not accumulate in specifically in mast cells[2].
References	[1]. Bruce I, et al. Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorg Med Chem Lett. 2012;22(17):5445-5450. [2]. Collmann E, et al. Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy. J Allergy Clin Immunol. 2013;132(4):959-968.

Molecular Formula	C₂₀H₂₆N₄O₃S
Molecular Weight	402.51

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