941580-60-5

941580-60-5 structure
941580-60-5 structure
  • Name: NVS-PI3-4
  • Chemical Name: NVS-PI3-4
  • CAS Number: 941580-60-5
  • Molecular Formula: C20H26N4O3S
  • Molecular Weight: 402.51
  • Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
  • Create Date: 2021-09-13 11:45:26
  • Modify Date: 2024-01-16 09:25:51
  • NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases[1][2].

Name NVS-PI3-4
Description NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases[1][2].
Related Catalog
Target

PI3Kγ

In Vitro NVS-PI3-4 shows an exquisite cellular selectivity for PI3Kγ. NVS-PI3-4 reduces IgE/antigen-mediated phosphorylation of PKB/Akt in p110δDA. NVS-PI3-4 (5 μM; 30 minutes; BMMCs) is not accumulate in specifically in mast cells[2].
References

[1]. Bruce I, et al. Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorg Med Chem Lett. 2012;22(17):5445-5450.

[2]. Collmann E, et al. Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy. J Allergy Clin Immunol. 2013;132(4):959-968.

Molecular Formula C20H26N4O3S
Molecular Weight 402.51