2389235-01-0
2389235-01-0 structure
- Name: NX-13
- Chemical Name: NX-13
- CAS Number: 2389235-01-0
- Molecular Formula: C24H21N3O3
- Molecular Weight: 399.44
- Catalog: Signaling Pathways Immunology/Inflammation NOD-like Receptor (NLR)
- Create Date: 2021-09-05 17:30:41
- Modify Date: 2024-01-11 14:04:55
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NX-13 is a first-in-class, orally active and gut-restricted agent that selectively targets and activates the NLRX1 pathway to induce immunometabolic changes. NX-13 results in lower inflammation and responses in inflammatory bowel disease. NX-13 can be used for the research of crohn's disease and ulcerative colitis[1][2].
| Name | NX-13 |
|---|
| Description | NX-13 is a first-in-class, orally active and gut-restricted agent that selectively targets and activates the NLRX1 pathway to induce immunometabolic changes. NX-13 results in lower inflammation and responses in inflammatory bowel disease. NX-13 can be used for the research of crohn's disease and ulcerative colitis[1][2]. |
|---|---|
| Related Catalog | |
| Target |
NLRX1 |
| In Vivo | NX-13 (0, 500, or 1000 mg/kg; oral gavage; 7 days) reduces ALP levels[2]. NX-13 (1 and 10 mg/kg; oral gavage; 0~24 hours) reaches the distal gastrointestinal tract[2]. Animal Model: Sprague Dawley rats (six weeks age)[2] Dosage: 0, 500, or 1000 mg/kg Administration: Oral gavage; 7 days Result: ALP in rats given the 1000 mg/kg dose level was lower than that in rats given 500 mg/kg. Animal Model: Male C57BL/6J mice (8-10 weeks age)[2] Dosage: 1 and 10 mg/kg (Pharmacokinetics analysis) Administration: Oral gavage; 24 hours Result: Reached the distal gastrointestinal tract. |
| References |
| Molecular Formula | C24H21N3O3 |
|---|---|
| Molecular Weight | 399.44 |