Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PLX7922
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

1638772-61-8

1638772-61-8 structure

1638772-61-8 structure

Name: PLX7922
Chemical Name: PLX7922
CAS Number: 1638772-61-8
Molecular Formula: C₂₀H₂₅FN₆O₂S₂
Molecular Weight: 464.58
Catalog: Signaling Pathways MAPK/ERK Pathway Raf
Create Date: 2021-09-05 19:57:01
Modify Date: 2024-01-14 05:45:45
PLX7922, a RAF inhibitor, can bind with BRAFV600E. PLX7922 inhibits pERK in BRAFV600E cell lines, and activates pERK in mutant NRAS cell lines[1].

Name	PLX7922

Description	PLX7922, a RAF inhibitor, can bind with BRAFV600E. PLX7922 inhibits pERK in BRAFV600E cell lines, and activates pERK in mutant NRAS cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Raf
Target	RAF[1]
In Vitro	PLX7922 (1-1000 nM) inhibits pERK in BRAFV600E cell lines, activates pERK in mutant NRAS cell lines (B9 and IPC-298)[1].
References	[1]. Zhang C, et, al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015 Oct 22;526(7574):583-6.

Molecular Formula	C₂₀H₂₅FN₆O₂S₂
Molecular Weight	464.58

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.