PLX7922

Modify Date: 2024-01-14 05:45:45

PLX7922 Structure
PLX7922 structure
Common Name PLX7922
CAS Number 1638772-61-8 Molecular Weight 464.58
Density N/A Boiling Point N/A
Molecular Formula C20H25FN6O2S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PLX7922


PLX7922, a RAF inhibitor, can bind with BRAFV600E. PLX7922 inhibits pERK in BRAFV600E cell lines, and activates pERK in mutant NRAS cell lines[1].

 Names

Name PLX7922

 PLX7922 Biological Activity

Description PLX7922, a RAF inhibitor, can bind with BRAFV600E. PLX7922 inhibits pERK in BRAFV600E cell lines, and activates pERK in mutant NRAS cell lines[1].
Related Catalog
Target

RAF[1]

In Vitro PLX7922 (1-1000 nM) inhibits pERK in BRAFV600E cell lines, activates pERK in mutant NRAS cell lines (B9 and IPC-298)[1].
References

[1]. Zhang C, et, al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015 Oct 22;526(7574):583-6.

 Chemical & Physical Properties

Molecular Formula C20H25FN6O2S2
Molecular Weight 464.58
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