2095064-09-6

2095064-09-6 structure

Name: (R)-Posenacaftor sodium
Chemical Name: (R)-Posenacaftor sodium
CAS Number: 2095064-09-6
Molecular Formula: C₂₇H₂₆NNaO₅
Molecular Weight: 467.49
Catalog: Signaling Pathways Membrane Transporter/Ion Channel CFTR
Create Date: 2021-09-12 12:25:49
Modify Date: 2024-01-16 18:27:47
(R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. Posenacaftor is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF)[1].

Name	(R)-Posenacaftor sodium

Description	(R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. Posenacaftor is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF)[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR Research Areas >> Inflammation/Immunology
Target	IC50: CFTR[1]
In Vitro	Cystic fibrosis (CF) is an autosomal recessive disorder, caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR)[1]. CFTR is a cAMP-regulated chloride channel that is primarily located at the apical membrane of epithelial cells. Mutations in the CFTR gene lead to the production of a defective and misfolded CFTR protein, and impairs the flow of ions in and out of cells[1]. Posenacaftor is a CFTR corrector, correctors are designed to fix and restore the function of the defective CFTR protein. The corrected CFTR then moves to the cell surface, where it functions as a chloride channel and helps maintain the right balance of fluid in the airways[2].
References	[1]. Benjamin Kopp, et al. Compositions et procédés pour améliorer la fonction cftr dans des cellules affectées par la fibrose kystique. Patent WO2019156946.

Molecular Formula	C₂₇H₂₆NNaO₅
Molecular Weight	467.49