607372-46-3
607372-46-3 structure
- Name: SB-747651A
- Chemical Name: SB-747651A
- CAS Number: 607372-46-3
- Molecular Formula: C16H22N8O
- Molecular Weight: 342.40
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2021-09-12 18:53:10
- Modify Date: 2025-08-24 21:33:39
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SB-747651A is a specific mitogen- and stress-activated kinase 1 (MSK1) inhibitor. SB-747651A can be used for the research of inflammation[1].
| Name | SB-747651A |
|---|
| Description | SB-747651A is a specific mitogen- and stress-activated kinase 1 (MSK1) inhibitor. SB-747651A can be used for the research of inflammation[1]. |
|---|---|
| Related Catalog | |
| Target |
MSK1[1] |
| In Vitro | SB-747651A (5 μM; neutrophils) affects CXCL2-induced intraluminal crawling of neutrophils in a Mac-1-dependent manner. SB-747651A thwarts the intraluminal crawling of adherent neutrophils to optimal sites of emigration. SB-747651A (5 μM; neutrophils) significantly increases transmigration time and detachment time. SB-747651A affects mechanisms that regulate transendothelial migration of neutrophils in response to CXCL2 chemotactic gradient. SB-747651A inhibits the migration speed of extravascular chemotaxing neutrophils but does not affect their directionality in response to CXCL2 chemotactic gradient[1]. |
| In Vivo | SB747651A (3 mg/kg; intrascrotal injection) results in increased neutrophil adhesion 3.5~4.5 hours following stimulation with CXCL2 as compared to the effect of CXCL2[1]. SB-747651A (3 mg/kg; i.p.) affects neutrophil extravasation by increasing neutrophil emigration only at 3 and 4 hours in mouse peritonitis model of acute inflammation[1]. Animal Model: Male C57BL/6N mice (8~16 weeks)[1] Dosage: 3 mg/kg Administration: Intrascrotal injection Result: Resulted in increased neutrophil adhesion 3.5~4.5 hours following stimulation with CXCL2 as compared to the effect of CXCL2. Animal Model: Male C57BL/6N mice (8~16 weeks)[1] Dosage: 3 mg/kg Administration: I.p. Result: Affected neutrophil extravasation by increasing neutrophil emigration only at 3 and 4 hours in mouse peritonitis model of acute inflammation. |
| References |
| Molecular Formula | C16H22N8O |
|---|---|
| Molecular Weight | 342.40 |