303-70-8

303-70-8 structure

Name: 11-[3-(dimethylamino)propyl]-5,6-dihydrobenzo[b][1]benzazepin-3-ol
Chemical Name: 11-[3-(dimethylamino)propyl]-5,6-dihydrobenzo[b][1]benzazepin-3-ol
CAS Number: 303-70-8
Molecular Formula: C₁₉H₂₄N₂O
Molecular Weight: 296.40700
Create Date: 2016-08-20 04:31:31
Modify Date: 2025-08-29 18:20:31

Name	11-[3-(dimethylamino)propyl]-5,6-dihydrobenzo[b][1]benzazepin-3-ol
Synonyms	5-(3-(Dimethylamino)propyl)-2-hydroxy-10,11-dihydro-5H-dibenz(b,f)azepine 5H-Dibenz(b,f)azepin-2-ol,10,11-dihydro-5-(3-(dimethylamino)propyl) 5-(3-dimethylamino-propyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-2-ol 2-Hydroxy Imipramine Hydroxyimipramine N-(3-Dimethylamino-propyl)-2-hydroxy-iminodibenzyl 2-OH-IP

Density	1.107g/cm3
Boiling Point	469ºC at 760mmHg
Melting Point	130-132ºC
Molecular Formula	C₁₉H₂₄N₂O
Molecular Weight	296.40700
Flash Point	239.5ºC
Exact Mass	296.18900
PSA	26.71000
LogP	3.64560
Index of Refraction	1.593

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HO2975500

CHEMICAL NAME :: 5H-Dibenz(b,f)azepin-2-ol, 10,11-dihydro-5-(3-(dimethylamino)propyl)-

CAS REGISTRY NUMBER :: 303-70-8

BEILSTEIN REFERENCE NO. :: 1547775

LAST UPDATED :: 199803

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C19-H24-N2-O

MOLECULAR WEIGHT :: 296.45

WISWESSER LINE NOTATION :: T C676 BN&T&J B3N1&1 FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2980 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1617,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1617,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 733 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1617,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 29 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,187,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 12500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1617,1969 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 300 mg/kg

SEX/DURATION :: female 8-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1617,1969

HS Code	2933990090

50-49-7

~1%

796-28-1

303-70-8

94436-87-0

Literature: Tetrahedron Letters, , vol. 52, # 7 p. 749 - 752

113-52-0

50-47-5

303-70-8

Literature: Journal of Pharmacology and Experimental Therapeutics, , vol. 281, # 3 p. 1199 - 1210

134150-88-2

303-70-8

Literature: Organic Preparations and Procedures International, , vol. 23, # 3 p. 365 - 372

113-52-0

303-70-8

Literature: Organic Preparations and Procedures International, , vol. 23, # 3 p. 365 - 372

6487-79-2

303-70-8

Literature: Organic Preparations and Procedures International, , vol. 23, # 3 p. 365 - 372

113-52-0

50-47-5

494-19-9

796-28-1

Detail

Literature: Journal of Pharmaceutical Sciences, , vol. 70, # 2 p. 151 - 155

113-52-0

494-19-9

796-28-1

303-70-8

Detail

Literature: Journal of Pharmaceutical Sciences, , vol. 70, # 2 p. 151 - 155

Precursor 4
50-49-7 113-52-0 134150-88-2 6487-79-2
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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