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50-47-5

50-47-5 structure
50-47-5 structure
  • Name: Desipramine hydrochloride
  • Chemical Name: desipramine
  • CAS Number: 50-47-5
  • Molecular Formula: C18H22N2
  • Molecular Weight: 266.38100
  • Catalog: API Nervous system medication Antidepressant, manic
  • Create Date: 2018-04-23 08:00:00
  • Modify Date: 2026-07-01 13:25:39
  • Desipramine is a tricyclic antidepressant. Desipramine inhibits the norepinephrine reuptake receptor in the central nervous system and reduces the sleep-related loss of genioglossus activity and improves pharyngeal collapsibility[1][2].
Name desipramine
Synonyms Desipramine D6
10,11-Dihydro-5-(3-methylaminopropyl)-5H-dibenz(b,f)azine
5H-Dibenzo[b, f]azine, N-(3-methylaminopropyl)
Demethylimipramine
Desipramine
5H-Dibenz[b,f]azine-5-propanamine, 10,11-dihydro-N-methyl
Pentofran
esipramine
DESIPRAMINE //BP
Monodemethylimipramine
Norimipramine
3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine
Methylaminopropyliminodibenzyl
3-(10,11-Dihydro-5H-dibenzo[b,f]azin-5-yl)-N-methylpropan-1-amine
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine
3-(10,11-dihydrodibenz(b,f)azin-5-yl)methylpropylamine
DESIPRAMINE
AURORA KA-7618
5-(3-methylaminopropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine
[14C]-Desipramine
Pertofrane
DESIPRAMINE,1.0MG/MLINMETHANOL
Dezipramine
Desipramin
Desipramine (base and/or unspecified salts)
Pertrofane
10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenz(b,f)azepin
Imipramine, demethyl
N-[3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZIN-5-YL)PROPYL]-N-METHYLAMINE HYDROCHLORIDE
Desimipramine
TIMTEC-BB SBB002569
5H-Dibenz[b,f]azine, 10,11-dihydro-5-[3-(methylamino)propyl]
[3H]-Desipramine
Desimpramine
3-(10,11-Dihydro-5H-dibenzo[b,f]azin-5-yl)-N-methyl-1-propanamine
Desmethylimipramine
Dimethylimipramine
Sertofran
EINECS 200-040-0
Description Desipramine is a tricyclic antidepressant. Desipramine inhibits the norepinephrine reuptake receptor in the central nervous system and reduces the sleep-related loss of genioglossus activity and improves pharyngeal collapsibility[1][2].
Related Catalog
Target

Norepinephrine Reuptake Receptor[1]

References

[1]. Garcia AS, et al. Autoreceptor-mediated inhibition of norepinephrine release in rat medial prefrontal cortex is maintained after chronic desipramine treatment. J Neurochem. 2004 Nov;91(3):683-93.

[2]. Taranto-Montemurro L, et al. Desipramine improves upper airway collapsibility and reduces OSA severity in patients with minimal muscle compensation. Eur Respir J. 2016 Nov;48(5):1340-1350.
Density 1.047 g/cm3
Boiling Point 407.4ºC at 760 mmHg
Melting Point 212°C
Molecular Formula C18H22N2
Molecular Weight 266.38100
Flash Point 160.5ºC
Exact Mass 266.17800
PSA 15.27000
LogP 3.98870
Index of Refraction 1.5200 (estimate)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HO0350000
CHEMICAL NAME :
5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(methylamino)propyl)-
CAS REGISTRY NUMBER :
50-47-5
BEILSTEIN REFERENCE NO. :
1432747
LAST UPDATED :
199706
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C18-H22-N2
MOLECULAR WEIGHT :
266.42
WISWESSER LINE NOTATION :
T C676 BN&T&J B3M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
1643 mg/kg/1Y-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Cardiac - pulse rate increase, without fall in BP Nutritional and Gross Metabolic - body temperature increase
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - coma Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Behavioral - coma Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
375 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
48 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
183 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
29 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
448 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
85 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
214 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
12 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
16250 ug/kg
SEX/DURATION :
female 8-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral

MUTATION DATA

TEST SYSTEM :
Insect - not otherwise specified
DOSE/DURATION :
10 gm/L
REFERENCE :
JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10003) V.12- 1962- Volume(issue)/page/year: 47,182a,1970 *** REVIEWS *** TOXICOLOGY REVIEW DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 8,690,1974
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases 36
WGK Germany 3
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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