2378855-09-3
2378855-09-3 structure
- Name: VRK-IN-1
- Chemical Name: VRK-IN-1
- CAS Number: 2378855-09-3
- Molecular Formula: C18H11F4NO2
- Molecular Weight: 349.28
- Catalog: Research Areas Neurological Disease
- Create Date: 2021-10-08 16:43:47
- Modify Date: 2024-01-14 12:43:11
-
VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders[1].
| Name | VRK-IN-1 |
|---|
| Description | VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 150 nM (VRK1)[1] |
| In Vitro | VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a Kd of 190 nM[1]. VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM[1]. |
| References |
| Molecular Formula | C18H11F4NO2 |
|---|---|
| Molecular Weight | 349.28 |