VRK-IN-1
Modify Date: 2024-01-14 12:43:11
VRK-IN-1 structure
|
Common Name | VRK-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 2378855-09-3 | Molecular Weight | 349.28 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H11F4NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VRK-IN-1VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders[1]. |
| Name | VRK-IN-1 |
|---|
| Description | VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 150 nM (VRK1)[1] |
| In Vitro | VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a Kd of 190 nM[1]. VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM[1]. |
| References |
| Molecular Formula | C18H11F4NO2 |
|---|---|
| Molecular Weight | 349.28 |