Shanghai Nianxing Industrial Co., Ltd
China
Product Name: VU6000918
Price:
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: VU6000918
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

2101737-32-8

2101737-32-8 structure

2101737-32-8 structure

Name: VU6000918
Chemical Name: VU6000918
CAS Number: 2101737-32-8
Molecular Formula: C₁₈H₁₇F₂N₅OS
Molecular Weight: 389.42
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2021-09-13 23:04:33
Modify Date: 2024-01-11 11:49:02
VU6000918 is a muscarinic acetylcholine (M4) positive allosteric modulator, with an EC50 of 19 nM for hM4[1].

Name	VU6000918

Description	VU6000918 is a muscarinic acetylcholine (M4) positive allosteric modulator, with an EC50 of 19 nM for hM4[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	EC50: 19 nM (hM4)[1].
In Vitro	VU6000918 demonstrates statistically significant AHL reversal (18%) from a low oral dose of 0.03 mg/kg and reaches maximal reversal (74%) from a 3 mg/kg dose, with a resulting in vivo plasma EC50 of 74 nM (0.66 nM unbound) based on terminal concentrations measured in the study animals (1.5 hr post-administration of 17j)[1].
References	[1]. James C Tarr, et al. Challenges in the development of an M 4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides. Bioorg Med Chem Lett. 2017 Jul 1;27(13):2990-2995.

Molecular Formula	C₁₈H₁₇F₂N₅OS
Molecular Weight	389.42